Our label lists Folate at 442mcg DFE (111% DV). If you have ever wondered what DFE means and why it is not just listed as milligrams of folic acid, you are asking a genuinely important question about supplement label literacy.
DFE stands for Dietary Folate Equivalents — a standardized unit that accounts for the different bioavailabilities of natural folate (from food) and synthetic folic acid (used in supplements). Folic acid is absorbed roughly 1.7 times more efficiently than food folate, so 260mcg of folic acid equals 442mcg DFE.
Gelagen contains 260mcg of folic acid, expressed as 442mcg DFE per FDA labeling requirements. This provides 111% of Daily Value.
Folate is essential for DNA synthesis and cell division. Skin, hair and nail cells are among the fastest-dividing cells in your body. Adequate folate ensures these tissues have the building blocks for proper replication.
Some people have genetic variants (MTHFR polymorphisms) that reduce their ability to convert folic acid to the active form. For these individuals, methylfolate (5-MTHF) supplements may be more appropriate. Our formula uses standard folic acid, which works well for the majority of the population.